A phenolic compound in VOO that stands alone in terms of sensory and anti-inflammatory attributes is decarboxy methyl ligstroside aglycone (also known as oleocanthal) []. Oleocanthal is homologous with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen [] for both perceptual and anti-inflammatory properties. Both compounds produce a localised irritation in the oropharangeal region and further research instigated, because of the perceptual similarities, found that oleocanthal shares a similar anti-inflammatory action with Ibuprofen [] therefore oleocanthal is now acknowledged as a naturally occurring NSAID [,,,,].

Importantly it has been proposed that the long term daily ingestion of virgin olive oil (containing oleocanthal), which is a common attribute of the traditional Mediterranean diet, may be partially responsible for the favorable health profile of Mediterranean populations [19].

Source: Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the Beneficial Effects on Inflammatory Disease

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